{"id":44748,"date":"2026-02-18T13:14:07","date_gmt":"2026-02-18T12:14:07","guid":{"rendered":"https:\/\/badania.uew.pl\/?p=44748"},"modified":"2026-02-18T13:29:54","modified_gmt":"2026-02-18T12:29:54","slug":"monk-fruit-extract-under-clinical-scrutiny-a-polish-rct-review-lower-postprandial-glycaemia-and-a-smaller-insulin-response-with-no-serious-adverse-events","status":"publish","type":"post","link":"https:\/\/badania.uew.pl\/en\/monk-fruit-extract-under-clinical-scrutiny-a-polish-rct-review-lower-postprandial-glycaemia-and-a-smaller-insulin-response-with-no-serious-adverse-events\/","title":{"rendered":"Monk fruit extract under clinical scrutiny. A Polish RCT review: lower postprandial glycaemia and a smaller insulin response, with no serious adverse events"},"content":{"rendered":"\n
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Can you reduce sugar in the diet without the \u201cpenalty\u201d of rapid spikes in glucose and insulin? This question was examined by Urszula Kaim (Wroc\u0142aw University of Economics and Business) and Karolina Labus (Wroc\u0142aw University of Science and Technology) in an article published in \u201cNutrients\u201d: \u201cMonk Fruit Extract and Sustainable Health: A PRISMA-Guided Systematic Review of Randomized Controlled Trials\u201d. The paper is a systematic review of clinical studies on monk fruit extract (Siraitia grosvenorii; monk fruit extract\u2014MFE), prepared in line with PRISMA methodology and based on randomised controlled trials (RCTs) conducted between 2015 and 2025.<\/strong><\/p>\n\n\n\n

\"Ekstrakt<\/figure>\n\n\n\n

Five RCTs and diverse protocols: the scope of the review<\/strong><\/h2>\n\n\n\n

The authors included five RCTs. The trials differed in protocol (from postprandial tests to short interventions lasting days to weeks) and in how MFE was administered (e.g., beverages, dairy products, lozenges), which is important for interpreting results and comparing evidence across studies.<\/p>\n\n\n\n

Key takeaways: what do the clinical studies show?<\/strong><\/h2>\n\n\n\n

First: postprandial glycaemia and insulin<\/strong><\/p>\n\n\n\n

In RCTs where MFE replaced sucrose, postprandial glycaemia decreased by around 10\u201318% and the insulin response by 12\u201322% compared with sugar. This suggests that MFE may reduce the \u201cmetabolic cost\u201d of sweet taste when the goal is to reduce sugar intake.<\/p>\n\n\n\n

Second: appetite for sweets<\/strong><\/p>\n\n\n\n

The review also noted findings suggesting a reduction in cravings for sweets (around 23%) and a small decrease in fasting glucose (around 6%). However, these results come from single studies and require replication in larger, longer trials.<\/p>\n\n\n\n

Third: uses beyond metabolism (throat)<\/strong><\/p>\n\n\n\n

The included evidence also covered studies assessing Siraitia grosvenorii preparations in the context of throat complaints; improvements were reported in outcomes such as sore throat, hoarseness, and mucosal irritation (including in clinical contexts such as post-intubation symptoms).<\/p>\n\n\n\n

Fourth: safety<\/strong><\/p>\n\n\n\n

No serious adverse events were reported in the analysed RCTs, supporting a favourable safety profile\u2014while noting that most trials were short and long-term data remain limited.<\/p>\n\n\n\n

Recipe reformulation and metabolic prevention: the growing role of evidence<\/strong><\/h2>\n\n\n\n

Reducing sugar intake is a key element of metabolic disease prevention, and the market needs solutions that combine sensory acceptability with a predictable metabolic profile. This review consolidates the available clinical evidence on MFE and shows where \u201cpromise\u201d ends and the hard need for further studies begins (larger trials, longer follow-up, clinical populations).<\/p>\n\n\n\n

Regulation: USA\/China\u2014yes; the EU\u2014status depends on the form and the authorisation pathway
Regulatory conclusions are not uniform. The article notes that MFE is authorised for use, among others, in the USA and China, while in the European Union the picture remains more complex. Independent regulatory analyses also indicate that \u201cmonk fruit\u201d may fall under different legal categories depending on its form (e.g., aqueous infusions\/decoctions vs highly purified mogrosides), and that at least one specific form of an aqueous extract has obtained authorisation in the EU (as of October 2024).<\/p>\n\n\n\n

What\u2019s next? Research gaps highlighted by the authors<\/strong><\/h2>\n\n\n\n

The review emphasises the need for higher-powered and longer-duration studies, better evidence on the effects of regular consumption, and deeper investigation into areas such as gut microbiota and cardiovascular parameters.<\/p>\n\n\n\n

When a review reaches wider audiences: a readership distinction<\/strong><\/h2>\n\n\n\n

\u201cThe publication attracted strong interest from international readers. The article received the \u2018Most Viewed Papers in 2025\u2019 distinction, meaning it ranked among the most frequently viewed items in its distribution channel in 2025. In practice, this signals growing visibility of the topic across both academic and science-informed public discourse\u2014particularly in the context of nutrition and metabolic disease prevention\u2014and confirms that RCT-based systematic reviews reach a broad audience.\u201d<\/p>\n\n\n\n

Citation:
Kaim, U.; Labus, K. Monk Fruit Extract and Sustainable Health: A PRISMA-Guided Systematic Review of Randomized Controlled Trials. Nutrients 2025, 17, 1433<\/a><\/p>\n\n\n\n

badania.uew.pl \u2013 because the world needs competent voices when research evidence matters more than dietary fads.<\/strong><\/p>\n\n\n

Tagi:<\/strong> <\/span>Urszula Kaim<\/a><\/div>\n\n\n

Author: Justyna Morawska-P\u0142oskonka<\/strong><\/p>\n<\/div>\n<\/div>\n\n\n\n

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Can you reduce sugar in the diet without the \u201cpenalty\u201d […]<\/p>\n","protected":false},"author":80,"featured_media":44730,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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